Pharmacokinetics of Compounded Chlorambucil in Cats with Cancer

Patient Disease:

Feline Small Cell Lymphoma

Study Name:

Pharmacokinetics of Compounded Chlorambucil in Cats with Cancer

Purpose of the study:

  • To understand the pharmacokinetics (absorption, distribution, metabolism, and excretion), relative bioavailability, and potency of compounded formulations of chlorambucil in cats with small cell GI lymphoma

Primary Eligibility Criteria:

  • Cats with a confirmed diagnosis of small cell lymphoma
  • Weigh at least 2.5 kg (5.5 lb)
  • Good function of liver and kidneys, acceptable blood cell counts, and free of severe underlying disease
  • FeLV/FIV negative
  • No current treatment with chlorambucil
  • Two-week washout from most chemotherapy drugs
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Within 14 days of enrollment, cats must have a complete blood count, chemistry profile, and urinalysis to determine study eligibility
  • On Day 0, cats will have an IV catheter placed and baseline blood sample obtained, be administered a dose of oral compounded chlorambucil and then have four more blood samples collected throughout the day
  • Cats must be fasted starting at midnight prior to the study visit • After this visit, clinical trial participation will be complete

Owner Responsibilities:

  • Follow appointment schedule required by study protocol
  • Costs associated with initial exam fee, tests to obtain diagnosis of small cell lymphoma, and any other tests recommended by your pet’s oncologist

Financial Incentives:

  • The study will cover all costs associated with the screening and study visits, including hospitalization during the day, cost of supplies, and medications given during these visits
  • Once cats have completed the study, owners will receive a $500 credit to their pet’s account at the VTH to be used for future treatment
  • Study will also pay up to $500 towards any complication or side effects from the study; treatment needs to be provided at CSU VTH for this to occur


If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.

flint animal cancer center newsletter

join our community

Be among the first to learn the latest Flint Animal Cancer Center news and pet cancer treatment information.
  • This field is for validation purposes and should be left unchanged.