COTC033: Repurposing Vaccine Immunity to Treat Cancers: Validation in Canine Patients

Patient Disease:

Canine Neoplasia (Multiple Types)

Study Name:

COTC033: Repurposing Vaccine Immunity to Treat Cancers: Validation in Canine Patients

Purpose of the study:

  • To evaluate the anti-cancer activity of repurposed vaccine-based immunity when given to tumor bearing dogs

Primary Eligibility Criteria:

  • Weight at least 15 kg (33 lb) but no more than 60 kg (132 lb)
  • Histologically or cytologically confirmed diagnosis of neoplasia other than mast cell tumor, thyroid carcinoma, lymphoma, or cutaneous hemangiosarcoma
  • Tumor must be 2-12 cm in diameter and accessible for biopsy
  • Adequate blood work
  • Two-week washout from chemotherapy or radiation therapy, 7-day washout from steroids
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Dogs randomized to receive either Shingrix/Gardasil vaccines or rabies vaccine
  • Dogs will receive 1-3 weekly vaccines into the muscle of a hindlimb in the primer phase, then two weeks later will start weekly injections directly into the tumor for 8 treatments
  • Tumor biopsies and lymph node aspirates will be performed at the time of the 1st, 5th, 24 hours after the 5th, and one week after the 8th vaccines
  • Blood will be collected for study purposes at each visit
  • The study is complete one week after the 8th vaccine

Owner Responsibilities:

  • You are responsible for the initial testing to determine study eligibility and any other tests recommended by your pet’s oncologist
  • You are expected to make and keep all appointments associated with the study

Financial Incentives:

  • All costs related to the study are covered, including the chest x-rays and abdominal ultrasound prior to enrollment and during the study, exam fees, blood and urine tests, lymph node aspirates, tumor biopsies, and the cost of the study treatments
  • $1000 credit given to pet’s account at the VTH at time of study withdrawal to be put towards additional treatment

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.

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