Patient Disease:

Canine Glioma

Study Name:

Canine Brain Tumor Vaccine Clinical Trial

Purpose of the study:

  • Evaluation of preliminary tumor response to vaccine that targets cancer stem cells as well as vaccine tolerability

Primary Eligibility Criteria:

  • Dogs with glioma type tumors based on MRI characteristics
  • Patients must still be in overall good health and stable condition
  • Not dependent on prednisone to control clinical signs
  • Seizures (if occurring) must be controlled with anti-convulsant medication
  • Measureable disease present and visible on MRI
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Pre-enrollment screening: physical/neurological exam, blood tests, MRI of the brain
  • Needle biopsy to confirm glioma diagnosis
  • Treatment of tumor with stereotactic radiotherapy (SRT)
  • Vaccination, physical exam, study blood sampling every other week for 6 treatments then monthly boosters
  • Follow up MRI scans at 6th vaccine treatment and then every 3 months

Owner Responsibilities:

  • You are responsible for initial screening tests (consultation/physical exam, blood and urine tests, MRI of brain)
  • You are expected to make and keep all appointments associated with the study

Financial Incentives:

  • Study will pay for all costs associated with the biopsy and SRT at the initial visit
  • All study medications will be covered
  • The study will pay for every other recheck MRI
  • Recheck MRIs that will be owner’s responsibility will be discounted 50%
  • Adverse events directly associated with the vaccine will be covered by the study
  • In the event of the patient’s death, necropsy and private cremation will be covered by the study

If you have further questions about this clinical trial, please email [email protected] or call (970) 297-4405.