Patient Disease:

Canine Osteosarcoma with Metastasis to the Lungs

Study Name:

CAR T cell Immunotherapy for Treatment of Metastatic Osteosarcoma in Dogs

Purpose of the study:

  • To determine the safety and effectiveness of canine CAR T cells in dogs with metastatic OSA

Primary Eligibility Criteria:

  • Dogs with a confirmed diagnosis of osteosarcoma via surgery to remove their primary tumor with measurable metastatic disease in the lungs visible on chest X-rays
  • Minimum weight 20 kg (44 lb)
  • Adequate blood work • 2-3 week washout from chemotherapy
  • No metastatic disease anywhere besides the lungs
  • No concurrent treatment with any immune modulatory drugs including corticosteroids
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Dogs will receive an IV infusion of CAR T cells. The blood for this procedure will be drawn two weeks prior to administration, and dogs will be treated with a bone marrow-suppressing drug (cyclophosphamide) for 4 days before the CAR T cells are given back
  • Dogs will also be prescribed daily oral losartan and propranolol to start 2 weeks prior to CAR T administration and will receive these medications throughout the entire study
  • Recheck visits will be required 1, 3, 7, 14, 28, and 60 days after CAR T cell infusion for an exam, diagnostics, and study blood collection
  • The study is complete after the Day 60 visit

Owner Responsibilities:

  • You are responsible for the initial testing to determine study eligibility and any other tests recommended by your pet’s oncologist
  • You will also be responsible for the costs of all exam fees throughout the duration of the study
  • You are expected to make and keep all appointments associated with the study
  • You must be comfortable administering oral medications at home and keeping a record of drug administration and side effects

Financial Incentives:

  • Once your pet is enrolled, the study will cover all costs related to the clinical trial (including diagnostics, CAR T cell generation and infusion, and study blood collection and processing), other than recheck exam fees

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.