Patient Disease:

Canine Osteosarcoma

Study Name:

3D-Printed Implant that Replaces Bone for Limb Sparing in Giant Breed Dogs with a Primary Bone Tumor

Purpose of the study:

  • To evaluate the use of a personalized 3D-printed implant made of a material that the body can replace with its own bone in limb sparing surgery in dogs with osteosarcoma

Primary Eligibility Criteria:

  • Dogs with suspected or confirmed osteosarcoma of the distal radius that meets previously established limb-sparing eligibility criteria
  • Giant breed and/or weight ≥ 40 kg (88lb)
  • Dogs must be free of detectable metastasis, and in good health otherwise
  • No concurrent medications that affect the immune system

Study Protocol:

  • Following entry into the study, dogs will have a whole body PET-CT scan
  • The images obtained with the CT scan will be used to make the 3D-printed implants that will be used in the limb-sparing surgical procedure, which is anticipated to take 5 days or less
  • Two weeks after surgery, dogs will begin carboplatin chemotherapy, administered every three weeks for a total of 6 treatments
  • Follow-up bloodwork, orthopedic exams, gait analyses, and chest and limb x-rays will be performed at various points throughout the chemotherapy protocol and every 2 months thereafter until 20 months post-op
  • Some of these follow-up visits can be done with your regular veterinarian if you choose; however, the study will not be able to cover the costs of these visits

Owner Responsibilities:

  • You are responsible for the initial testing to determine study eligibility and any other tests recommended by your pet’s oncologist
  • You are responsible for the costs associated with the treatment of complications from the limb surgery beyond what the study provides
  • You are expected to make and keep all appointments associated with the study
  • When your dog passes away or is euthanized, the limb will need to be provided to study personnel
  • If any study visits are not performed at CSU, you will be responsible for those costs

Financial Incentives:

  • The study will cover the costs of the PET-CT to plan the personalized implant (including anesthesia), the personalized implant with the growth factor for bone, the special instruments required to do the surgery, the metal implants, and the costs of surgery and hospitalization
  • Costs associated with chemotherapy and the recheck visits with the x-rays of the operated limb and chest (every 2 months) will also be covered by the study for 20 months
  • Up to $5,825 is available to cover the costs of complications of the surgery if they arise

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.