Preclinical Evaluation of TBX-3440 in Dogs with Neoplasia

Patient Disease:

Any Canine Neoplasia except T cell Lymphoma

Study Name:

Preclinical Evaluation of TBX-3440 in Dogs with Neoplasia

Purpose of the study:

  • To evaluate the early safety profile, immune system effects and antitumor activity of this a form of immunotherapy known as activated T cell therapy given to dogs with cancer

Primary Eligibility Criteria:

  • Dogs with a confirmed diagnosis of cancer except for T cell lymphoma
  • Good function of liver and kidneys, acceptable blood cell counts, and free of severe underlying disease
  • Three week washout from chemotherapy; no prior radiation therapy; 72 hour washout from steroids
  • No prior history of autoimmune disease or current treatment with immunosuppressive drugs
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Dogs will have a small amount of blood taken, and the immune cells will be isolated and treated with a protein in the laboratory and then given back as a rapid intravenous injection once every 4 weeks
  • Rechecks required 1 and 3 days after the first injection, then weekly for the first 4 weeks, then every other week thereafter
  • Analysis for tumor response will be performed by direct tumor measurement or through the use of imaging (radiographs, ultrasound, CT)
  • Standard bloodwork will be performed at each visit
  • Additional tests to be performed include blood draws and 2 or 3 biopsies of the tumor over the course of the study to determine how the treatment is affecting the cancer cells

Owner Responsibilities:

  • Follow appointment schedule required by study protocol

Financial Incentives:

  • All procedures related to the clinical trial will be covered by the study
  • Following completion of the clinical trial, a credit of $1000 will be applied to the VTH account for continued treatment at CSU

If you have further questions about any of our clinical trials, please submit anĀ online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.