Phase-1 Evaluation of Vismodegib Plus Carboplatin in Dogs with Spontaneous Osteosarcoma

Patient Disease:

Canine Osteosarcoma

Study Name:

Phase-1 Evaluation of Vismodegib Plus Carboplatin in Dogs with Spontaneous Osteosarcoma

Purpose of the study:

  • To evaluate the safety and molecular effects of vismodegib treatment, combined with surgery and chemotherapy, in dogs with osteosarcoma

Primary Eligibility Criteria:

  • Suspected or confirmed diagnosis of osteosarcoma of the limb for which owners plan to pursue limb amputation
  • Adequate blood work
  • No prior chemotherapy for the primary tumor
  • No measurable metastatic disease post-amputation
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Dogs will be treated with oral vismodegib once daily 2 weeks on/1 week off starting one week after limb amputation, and will receive 4 doses of carboplatin as an injection every 3 weeks
  • Recheck 2, 3, 4, 5, 8, 11, 14 and 17 weeks after treatment is started and monthly thereafter
  • Chest x-rays will be rechecked every other month
  • Blood samples will be collected for study purposes periodically, and small skin biopsies will be performed at the time of amputation and 2 and 8 weeks after starting vismodegib

Owner Responsibilities:

  • You are responsible for the initial testing to determine study eligibility and any other tests recommended by your pet’s oncologist, the costs of amputation surgery, and medications to prevent side effects associated with carboplatin treatment
  • You are expected to make and keep all appointments associated with the study
  • You must be comfortable administering oral medications at home

Financial Incentives:

  • The clinical trial will cover the costs of recheck examinations, blood and urine tests, and chemotherapy, and recheck chest X-rays
  • Up to $2,000 per patient is available to cover costs associated with the treatment of serious side effects requiring hospitalization or other care

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.

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