Pharmacokinetics of Oral Chlorambucil in Cats with Cancer

Patient Disease:

Feline Small Cell Lymphoma

Study Name:

Pharmacokinetics of Oral Chlorambucil in Cats with Cancer

Purpose of the study:

  • To understand how a cat’s body absorbs and metabolizes chlorambucil, a commonly used oral cancer drug for cats

Primary Eligibility Criteria:

  • Cats with a confirmed diagnosis of small cell lymphoma for which treatment with chlorambucil is recommended
  • Weigh at least 2.5 kg (5.5 lb)
  • Good function of liver and kidneys, acceptable blood cell counts, and free of severe underlying disease
  • No prior treatment with chlorambucil
  • Two-week washout from most chemotherapy drugs
  • Owners must be willing and able to administer oral medications to their cat
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Within 14 days of starting the study treatment, cats will have a complete blood count, chemistry profile, B12 level, and urinalysis to determine study eligibility
  • On Day 0, cats will have a baseline blood sample obtained, be administered his/her first dose of chlorambucil and then have three more blood samples collected throughout the day
  • Owners will continue to administer the oral chlorambucil at home once every other day, as is standard for treatment of small cell (low grade) lymphoma in cats
  • Cats will return on Day 14 for a recheck examination, complete blood count, and collection of another blood sample
  • After this visit, clinical trial participation will be complete

Owner Responsibilities:

  • Administer oral medication to their cats
  • Follow appointment schedule required by study protocol
  • Costs associated with initial exam fee, tests to obtain diagnosis of small cell lymphoma, and any other tests recommended by your pet’s oncologist

Financial Incentives:

  • The study will cover all costs related to the study, including the pre-enrollment diagnostics, procedures at each study visit, and two weeks of chlorambucil

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.

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