Incidence of Subclinical Tumor Lysis Syndrome in Dogs with Multicentric Lymphoma

Patient Disease:

Canine Lymphoma

Study Name:

Incidence of Subclinical Tumor Lysis Syndrome in Dogs with Multicentric Lymphoma

Purpose of the study:

  • To measure changes in blood gas parameters (lactate, pH) and changes in plasma inflammatory hormones for the first 24 hours after starting chemotherapy in dogs with lymphoma, and correlate these changes with changes in lymph node size measured 24 hours and 7 days after the start of treatment

Primary Eligibility Criteria:

  • Weight at least 9 kg (~20 lb)
  • Dogs with newly diagnosed lymphoma that will be treated with the CHOP chemotherapy protocol
  • No prior chemotherapy for lymphoma; 7 day washout from steroids required
  • Otherwise healthy and free of other major diseases
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Dogs will receive a standard dose of vincristine as the first treatment in the CHOP chemotherapy protocol
  • Vital signs (temperature, pulse, respiration) measured and blood collected (approximately 2 teaspoons per time point) multiple times after treatment (2, 4, 8 and 24 hours after vincristine is given)
  • Recheck 1 week following treatment for collection of additional blood and lymph node measurement.

Owner Responsibilities:

  • Costs of diagnostics to determine eligibility for clinical trial
  • Make and keep all appointments according to the treatment protocol

Financial Incentives:

  • All costs related to the blood draws and blood gas measurements that take place over the study week are paid for by study
  • Study covers costs associated with first vincristine treatment and of overnight stay at hospital for blood collection (if needed)

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.

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