Impact of Regional Lymph Node Irradiation on the Anti-Tumor Immune Response for Canine Patients with Sinonasal Carcinoma

Patient Disease:

Canine Sinonasal Tumors

Study Name:

Impact of Regional Lymph Node Irradiation on the Anti-Tumor Immune Response for Canine Patients with Sinonasal Carcinoma

Purpose of the study:

  • To determine how lymph node radiation affects the immune response mounted against cancer cells within the tumor and throughout the body

Primary Eligibility Criteria:

  • Dogs with a confirmed diagnosis of sinonasal carcinoma
  • Good function of liver and kidneys, acceptable blood cell counts, and free of severe underlying disease
  • No evidence of metastatic disease or extension of the tumor into the brain
  • One week washout from chemotherapy; no prior radiation to the tumor or regional lymph nodes

Study Protocol:

  • Once enrolled, dogs will undergo a CT scan for radiation planning purposes
  • Tumor samples will be collected via nasal flush prior to, during, and after radiation therapy
  • Dogs will be treated with 3 daily fractions of stereotactic body radiotherapy (SBRT)
  • Two weeks following the last treatment of radiotherapy, dogs will return to the hospital for additional tissue sampling, including surgical excision of one or two lymph nodes

Owner Responsibilities:

  • Follow appointment schedule required by study protocol
  • Payment of the remainder of the costs for SBRT to treat the oral tumor (CT scan for SBRT treatment planning, SBRT), medications, any other tests recommended, as well as in the case of adverse events unrelated to the study

Financial Incentives:

  • A $1,500 credit will be given to supplement treatment costs as incentive to participate in this study
  • Owners will not be charged for the additional diagnostic tests or sampling that are associated with this trial (blood work, nasal flush, lymph node aspirate, surgical excision of lymph node, additional anesthesia time) as these will be covered through the funding of the study
  • In the case of adverse events directly related to this trial, up to $2,000 will be provided to supplement the costs of supportive care
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