Impact of Regional Lymph Node Irradiation on the Anti-Tumor Immune Response for Canine Patients with Sinonasal Cancer

Trial ended April 2021.

Patient Disease:

Canine Sinonasal Cancer

Study Name:

Purpose of the study:

To determine how lymph node radiation affects the immune response mounted against cancer cells within the tumor and throughout the body

Primary Eligibility Criteria:

Dogs with a suspected or confirmed diagnosis of sinonasal cancer
Good function of liver and kidneys, acceptable blood cell counts, and free of severe underlying disease
No evidence of metastatic disease or extension of the tumor into the brain
One week washout from chemotherapy; no prior radiation to the tumor or regional lymph nodes
Dogs will undergo a CT scan to confirm eligibility and for radiation planning purposes

Study Protocol:

Tumor samples will be collected via nasal flush prior to, during, and after radiation therapy
Dogs will be treated with 3 daily fractions of stereotactic body radiotherapy (SBRT)
Two weeks following the last treatment of radiotherapy, dogs will return to the hospital for additional tissue sampling, including surgical excision of one or two lymph nodes

Owner Responsibilities:

Follow appointment schedule required by study protocol
Payment of the remainder of the costs for SBRT to treat the nasal tumor (CT scan for SBRT treatment planning, SBRT), medications, any other tests recommended, as well as in the case of adverse events unrelated to the study

Financial Incentives:

A $4,000 credit will be given to supplement treatment costs as incentive to participate in this study
Owners will not be charged for the additional diagnostic tests or sampling that are associated with this trial (blood work, nasal flush, lymph node aspirate, surgical excision of lymph node, additional anesthesia time) as these will be covered through the funding of the study
In the case of adverse events directly related to this trial, up to $2,000 will be provided to supplement the costs of supportive care

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.