Patient Disease:

Canine Osteosarcoma with Metastasis to the Lungs

Study Name:

Focal Adhesion Kinase (FAK) Inhibition for Dual Targeting of Lung Fibroblasts and Tumor Cells in Canine Metastatic Osteosarcoma

Purpose of the study:

  • To determine whether defactinib can provide cancer control in dogs with metastatic osteosarcoma
    • This drug may have direct anti-tumor effects as well as an ability to modulate the tumor-promoting microenvironment

Primary Eligibility Criteria:

  • Dogs with a confirmed diagnosis of osteosarcoma via surgery to remove their primary tumor with measurable metastatic disease in the lungs visible on chest x-rays
  • At least 1 year old; minimum weight 10 kg (22 lb)
  • Adequate blood work
  • Two week washout from any anti-cancer therapy
  • No prior treatment for lung metastasis
  • No metastatic disease anywhere besides the lungs
  • Pets must come to CSU for all visits related to the clinical trial

Study Protocol:

  • Dogs will be treated with oral defactinib (twice daily)
  • Serial blood samples will be collected in hospital for 8 hours after the first dose of defactinib
  • Rechecks will be required 2 and 4 weeks after starting treatment and every 4 weeks thereafter if tumors are stable or better
  • Chest x-rays will be rechecked at week 8 and then every 4 weeks while on study

Owner Responsibilities:

  • You are responsible for the initial testing to determine study eligibility and any other tests recommended by your pet’s oncologist
  • You will also be responsible for the costs of all exam fees, diagnostics (blood and urine tests, blood pressure monitoring, and chest x-rays), and any additional medications that are prescribed throughout the duration of the study beyond the $2,750 study incentive
  • You are expected to make and keep all appointments associated with the study
  • You must be comfortable administering oral medications at home

Financial Incentives:

  •  Defactinib will be provided at no cost other than the pharmacy dispensing fee ($8 per prescription)
  • $1,500 will be available to go towards the costs of study-related exams, diagnostics, and medications
  • If your pet stays on study beyond the week 8 visit, up to an additional $500 will be available to
    be applied toward study-related costs
  • Up to $500 is available to treat side effects related to the study drugs

If you have further questions about any of our clinical trials, please submit an online consult form. Your consult will then be directed to our trials team. Requests are typically returned within 5 business days.