LNMRI for Detecting Metastatic Lymph Nodes

Patient Disease:

Canine Oral Tumors (melanoma, fibrosarcoma, salivary carcinoma)

Study Name:

LNMRI for Detecting Metastatic Lymph Nodes

Purpose of the study:

  • To determine if a novel, non-invasive imaging method utilizing iron nanoparticles is more sensitive than other types of imaging for diagnosing metastatic lymph nodes

Primary Eligibility Criteria:

  • Dogs with a diagnosis of oral melanoma, oral fibrosarcoma, or salivary carcinoma; other oral tumor types may be eligible on a case-by-case basis

  • Surgical removal of primary tumor okay if surgical site can be easily identified

  • No prior chemotherapy or radiation to the head/neck region

  • No prior removal of head/neck lymph nodes

Study Protocol:

  • Day 1: Dogs anesthetized for short MRI followed by CT scan + lymph node mapping; after CT, iron nanoparticle drug is given as an IV infusion

  • Day 2: Anesthesia for repeat MRI 24-48 hours following drug infusion followed by surgical removal of lymph nodes identified as at risk for metastasis

Owner Responsibilities:

  • You are responsible for the initial testing to determine study eligibility (sampling of the primary tumor, chest radiographs and bloodwork; approximately $400-700 depending on the tests performed) and any other tests recommended by your pet’s oncologist

  • You are expected to make and keep all appointments associated with the study

Financial Incentives:

  • All costs related to the study protocol including the costs of imaging, drug infusion, and lymph node removal are covered by the study

  • ​​​​​​​Should your pet have any significant allergic reactions during administration of the medication and require hospitalization, the trial will pay for treatments associated with this incident only


If you have further questions about any of our clinical trials, please submit an online consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days.