Ultra-Small Paramagnetic Iron Oxide Particle MRI for Imaging Appendicular Canine Osteosarcoma

Patient Disease:

Canine Osteosarcoma

Study Name:

Ultra-Small Paramagnetic Iron Oxide Particle MRI for Imaging Appendicular Canine Osteosarcoma

Purpose of the study:

  • To develop a noninvasive way to determine how many tumor-associated macrophages (TAMs) are present in a bone tumor

  • The presence of TAMs in bone tumors has been show to be potentially associated with survival

Primary Eligibility Criteria:

  • Dogs with a diagnosis of bone cancer (osteosarcoma) of the limb

  • Adequate blood work

  • No prior chemotherapy, bisphosphonates, or radiation to the primary tumor

Study Protocol:

  • Day 1: Anesthesia for MRI of leg followed by iron nanoparticle drug given as an IV infusion

  • Day 3: Anesthesia for MRI 36-48 hours following drug infusion followed limb amputation

Owner Responsibilities:

  • You are responsible for the initial testing to determine study eligibility (limb and chest radiographs and bloodwork; approximately $400-700 depending on the tests performed) and any other tests recommended by your pet’s oncologist

  • You are expected to make and keep all appointments associated with the study

Financial Incentives:

  • All costs related to the study protocol including the costs of imaging and drug administration

  • $750 will be applied to your hospital bill that will help to cover the costs of the surgery

  • Should your pet have any significant allergic reactions during administration of the medication and require hospitalization, the trial will pay for treatments associated with this incident only


If you have further questions about any of our clinical trials, please submit an online consulting form. Your consult will then be directed to an appropriate oncology clinician. Requests are typically returned within 5 business days.