Rodney Page

Biography of Investigator:
Dr. Page, a veterinarian and an alumnus of CSU's College of Veterinary Medicine and Biomedical Sciences (Class of 1981), also holds an undergraduate degree from the University of Colorado at Boulder and a Master of Science in physiology from Georgetown University Medical School in Washington, D.C. Dr. Page comes to CSU from Cornell University where he was the founding director of the Sprecher Institute for Comparative Cancer Research and served as the chair for the Department of Clinical Sciences in the College of Veterinary Medicine. Prior to that, he spent 15 years with North Carolina State University's College of Veterinary Medicine where, in collaboration with other research centers, he helped to establish one of the first comparative veterinary oncology programs. After earning his DVM from CSU, Dr. Page served a three-year residency in clinical oncology at the esteemed Animal Medical Center in New York City.

Research Focus:
The primary interest of my research program has been to develop new products for cancer therapy and better ways to administer cancer therapy. This includes new anticancer compounds and various strategies for better dosing and improved combination of products for safer and more consistent effects. I have become interested recently in strategies to detect cancers earlier and to prevent cancers as a means to more effectively reduce the cancer burden.

Publications: (Selected publications from total of 114 refereed manuscripts.)

Waddle JR, Fine RL, Case BC, Trogdon ML, Tyczkowska K, Frazier D, Page, R.L. Phase I and pharmacokinetic analysis of high-dose tamoxifen plus chemotherapy in normal and tumor-bearing dogs. Cancer Chemotherapy and Pharmacology 44:74-80, 1999.

LaRue, S.M., Fox, M.H., Ogilvie, G.K., Page, R.L., Getzy, D.M., Thrall, D.E., Johnson, J.L., Dewhirst, M.W., and Gillette, E.L.: Tumor cell kinetics as predictors of response in canine lymphoma treated with chemotherapy alone or combined with whole body hyperthermia. Int. J. Hyperthermia 15:475-486, 1999.

Thrall DE, LaRue SM, Powers BE, Page, R.L., Johnson J, George SL, Kornegay JN, McEntee MC, Dewhirst MW, Gillette EL. Use of whole body hyperthermia as a method to uniformly heat inaccessible tumors: A phase III trial in canine brain masses. Int. J of Hyperthermia 15:383-388, 1999.

Vujaskovic, J., Poulson, J.M., Gaskin, A.A., Thrall, D.E., Page, R.L., Charles, H.C., MacFall, J.R., Brizel, D.M., Meyer, R.E., Prescott, D.M., Samulski, T.V., and Dewhirst, M.W.: Temperature-Dependent Changes in Physiologic Parameters of Spontaneous Canine Soft Tissue Sarcomas After Combined Radiotherapy and Hyperthermia Treatment. Int. J. Radiat. Oncol. Biol. Phys. 46:179-185, 2000.

Prescott, DM, Charles CC, Poulson JM, Page, R.L.,Thrall DE, Vujaskovic Z, Dewhirst MW. The relationship between intracellular and extracellular pH in spontaneous canine tumors. Clinical Cancer Research 6:2501-2505, 2000.

Case BC, Hauck ML, Yeager R, Page, R.L. Pharmacokinetics and pharmacodynamics of GW395058, a pegylated peptide agonist of the thrombopoietin receptor, in a large animal model of chemotherapy induced thrombocytopenia. Stem Cells 18:360-365, 2000.

Page, R.L., Hughes CS, Huyan S, Sagris J, Trogdon M. Modulation of P-glycoprotein-mediated doxorubicin resistance in canine cell lines. Anticancer Research 20:3533-3538, 2000.

Poulson JM, Dewhirst MW, Gaskin AA, Vujaskovic Z, Samulski TV, Prescott DM, Meyer RE, Page, R.L., Thrall DE. Acute pancreatitis associated with administration of a nitric oxide synthase inhibitor in tumor-bearing dogs. In Vivo 14:709-714, 2000.

Maitra, R, Halpin, PA, Carlson, KH, Page, R.L., Paik, DY, Moyer, D, Matthew, OL, Stanton, BA, Hamilton, JW. Differential effects of mitomycin C and doxorubicin on P-glycoprotein expression. Biochem J 355(3):617-623, May 2001.

Antonyak, MA, Ugra SS, Lee, DA, Boehm JE, Combs C, Zgola M, Page, R.L., Cerione RA. Effects of Tissue transglutaminase on retinoic acid-induced cellular differentiation and protection against apoptosis. J Biol Chem 276:33582-33586, 2001.

McEntee MC, Silverman JA, Rassnick KM, Zgola MM, Chan AO, Tau PT, Page, R.L. Enhanced bioavailability of oral docetaxel by co-administration of cyclosporine in dogs and rats. Veterinary and Comparative Oncology 1:105-112, 2003.

Manor D, Shmidt EN, Budhu A, Nikitin AF, Zgola M, Page, R.L., Noy N and Nikitin AY. Suppression of mammary tumor growth by cellular retinoic acid binding protein II. Cancer Res 63:4426-4433, 2003.

McEntee MC, Page, R.L., Theon A, Erb H, Thrall DE. Malignant tumor formation in dogs previously irradiated for oral acanthomatous epulis. Vet Radiol & US 45:357-361, 2004.

Antonyak MA, Miller AM, Jansen JM, Boehm JE, Balkman CE, Wakshlag JJ, Page, R.L., Cerione RA. Augmentation of tissue transglutaminase expression and activation by epidermal growth factor inhibits doxorubicin-induced apoptosis in human breast cancer cells. J Biol Chem. 279(40):41461-7, 2004.

Bailey DB, Rassnick KM, Erb HN, Dykes NL, Hoopes PJ, Page, R.L. Effect of glomerular filtration rate on carboplatin clearance and myelotoxicity in tumor-bearing cats. Am J of Veterinary Research 65:1502-1507, 2004.

Wakshlag JJ, McNeill CJ, Antonyak M, Boehm J, Fuji R, Balkman CE, Zgola M, Cerione R, Page, R.L. Expression and activity of transglutaminase II in normal tissue and spontaneous tumors of companion animals. J Comp Pathology Feb-Apr;134(2-3):202-10, 2006.

McEntee MC, Rassnick KM, Lewis LD, Zgola MM, Beaulieu BB, Balkman CE, Page, R.L. Phase I and Pharmacokinetic Evaluation of the Combination of Oral Docetaxel and Cyclosporin A in Tumor-Bearing Dogs. Am J Vet Res Jun;67(6): 1057-62, 2006.

Ying V, Haverstic K, Page, R.L., Saltzman M. Efficacy of camptothecin and polymer-conjugated Camptothecin in tumor spheroids and solid tumors. J Biomaterials Science, Polymer Edition 18:1283-1299, 2007.

Rassnick KM, Muindi JR, Johnson CS, Balkman CE, Ramnath N, Yu W, Engler KL, Page, R.L., Trump DL. In Vitro and In Vivo Evaluation of Combined Calcitriol and Cisplatin in Dogs with Spontaneously Occurring Tumors. Cancer Chemotherapy and Pharmacology 62(5):881-91, 2008.

Field MS, Anguera MC, Page, R.L., Stover PJ. 5,10-Methenyltetrahydrofolate Synthetase Activity is Increased in Tumors and Modifies the Efficacy of Antipurine LY309887. Archive of Biochemistry and Biophysics (In press 2008).

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