|Printer Friendly Page | View all Faculty / Researchers|
|Name of Investigator: Elizabeth P. Ryan
Title: Assistant Professor of Toxicology and Nutrition
Biography of Investigator:
During my service with the U.S. Peace Corps in Nepal, I conducted several trainings in conjunction with women’s health initiatives geared towards improving hygiene and nutrition for disease prevention and reducing environmental exposures. I have also conducted ecological and human health risk assessments as well as drafted/audited EPA Toxicological Profile reports while working at Tetra Tech NUS and consulting for Oak Ridge Institute for Science and Engineering (ORISE). I soon discovered that my strengths and passion to address major public health issues, specifically those regarding immunity and cancer were through hypothesis-driven research, and thus sought out postdoctoral training with a NCI Cancer Control and Prevention fellowship to translate laboratory findings of “reduced humoral immune responses by NSAIDs” to vaccine trials in the clinic.
This past year, while with the Crops for Health program at CSU, I have been studying the effects of food components on cellular metabolism, and with the goal of improving the interface between plant and biomedical scientists to improve the investigation of health promoting characteristics of foods available to humans and animals in the marketplace. This transdisciplinary initiative was to develop novel, sustainable breeding strategies that incorporate health traits, but are NOT related to genetic modification of foods. Rice feeds half of humanity, and the bran fraction is a rich source of chemicals and nutrients that is often not consumed. Our lab is now examining bioactive rice bran components for modulation of immunity and tumor metabolism. Alternative medicine practices with plant -derived compounds have been widely available and consumed in the western world, however limited evidence-based research exists for their use in conjunction with standard of care cancer treatments.
Cancer patients are among the largest consumers of natural product supplements, and my laboratory will utilize the canine cancer model to investigate clinically relevant drug-herb interactions. This program of research seeks to determine the safety and efficacy of herbal supplement use during chemotherapy, and thus contribute to evidence-based guidelines regarding complementary and alternative medicine strategies for cancer care in animals and humans.
Classes Taught/Currently Teaching:
Name of Laboratory:
Ryan Lab Supported by Grants from:
OPP1015267, Ryan (PI)
Dry Bean Health Research Program, Ryan (PI)
Foundation Support for Ryan Lab Research:
G. M. Forster, D. Hill, G. Gregory, K. M. Weishaar, S. Lana, J. E. Bauer and Ryan EP. Effects of cooked navy bean powder on apparent total tract nutrient digestibility and safety in healthy adult dogs. J ANIM SCI published online February 24, 2012.
Fu D., Ryan EP, Huang J, Liu Z., Weir T. Fermented Camellia sinensis, Fu Zhuan Tea, regulates hyperlipidemia and transcription factors involved in lipid catabolism. Food Research International, Volume 44, Issue 9, November 2011.
Angela J. Henderson, Ajay Kumar, Brittany Barnett, Steven W. Dow, and Ryan EP. Consumption of Rice Bran Increases Mucosal Immunoglobulin A Concentrations and Numbers of Intestinal Lactobacillus spp. Journal of Medicinal Food. doi:10.1089/jmf.2011.0213. (Epub ahead of print.)
Erica Daniell and Ryan EP(2012). The Nutrigenome and Gut Microbiome: Chronic Disease Prevention with Crop Phytochemical Diversity, The Molecular Basis of Plant Genetic Diversity, Prof. Mahmut Caliskan (Ed.), ISBN 978-953-51-0157-4, InTech.
Ryan EP. Bioactive Food Components and Health Properties of Rice bran. Journal of American Veterinary Medical Association. Timely Topics in Nutrition 2011 Mar 1;238(5):593-600.
Ryan EP, Heuberger A., Prenni J, Broekling C, and Weir T. Rice bran fermented with Saccharomyces boulardii generates novel metabolite profiles with bioactivity. Journal of Agriculture and Food Chemistry DOI: 10.1021/jf1038103. 2011. (Epub ahead of print.)
Caulum, MM., Fitzgerald, VK., Ryan EP, Lee, SG., Thompson, HJ., Brick, M. A., Evaluation of Diversity among Common Beans (Phaseolus vulgaris L.) from Two Centers of Domestication using 'OMICS' Technologies. BMC Genomics 11:686. 2010.
Heuberger, A, Chen, M. Lewis, M., Leach J. and Ryan EP. Integrated metabolomic and functional genomic analyses reveal varietal differences in bioactive compounds of cooked rice. PLOS One 5:e12195, 2010.
Ryan EP and Thompson HJ. "Design of Nutritional Interventions for Control of Oxidative Stress" Endogenous Toxins. Wiley Science 2010.
Bernard MP, Bancos S, Chapman TJ, Ryan EP, Treanor JJ, Rose RC, Topham DJ and RP Phipps. Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against Vaccinia infection. Vaccine Feb 3;28(5):1363-72. 2010.
Hawkins NA, Pollack LA, Leadbetter, S, Randolph Steele W, Carroll J, Dolan JG, Ryan EP, Ryan JL, and GR Morrow. Informational Needs of Patients and Perceived Adequacy of Information Available Before and After Treatment for Cancer. Journal of Psychosocial Oncology 26 (2):1-16. 2008.
Ryan EP, Rahman I, and RP Phipps. SC-58125 diminishes intracellular glutathione and induces reactive oxygen species by a Cox-2 independent mechanism in malignant B lineage cells. Cancer Immunology, Immunotherapy 57 (3):347-358. 2008.
Ryan JL, Carroll J, Ryan EP, Mustian K, Morrow GR. Mechanisms of Cancer Related Fatigue. The Oncologist 12 Suppl 1: 22-34. 2007.
Ryan EP, Holz J, Gasiewicz TA, E Puzas. Environmental toxicants may modulate osteoblast differentiation by a mechanism involving the aryl hydrocarbon receptor. Journal of Bone and Mineral Research 22:1571- 1580. 2007.
Figueroa-Moseley, C. Jean-Pierre, P., Roscoe, J, Ryan, JL., Kohli, S., Palesh, O., Ryan EP, Carroll, J., & Morrow, G. Behavioral interventions in the treatment of anticipatory nauseau and vomiting: Theoretical models, basic mechanisms, and clinical management. Journal of National Comprehensive Cancer Network Jan 5(1): 44-50. 2007.
Ryan EP, CM Malboeuf, RC Rose, RP Phipps. Cyclooxygenase-2 inhibition attenuates antibody responses against human papillomavirus-like particles. Journal of Immunology 177: 7811-7819. 2006.
Ryan EP, SJ Pollock, K Kaur, RE Felgar, SH Bernstein, N Chiorazzi, and RP Phipps. Constitutive and activation-inducible Cox-2 expression enhances survival of Chronic Lymphocytic Leukemia B cells. Clinical Immunology 120:76-90. 2006.
Ryan EP, SJ Pollock, TI Murant, RE Felgar, SH Bernstein, and RP Phipps. Activated human B lymphocytes express cyclooxygenase-2 and cyclooxygenase inhibitors attenuate antibody production. Journal of Immunology 174:2619-2626. 2005.
Phipps, RP, Ryan EP and SH Bernstein. Inhibition of cyclooxygenase-2: a new targeted therapy for B cell lymphoma. Leukemia Research 28:109-111. 2004.
Name: Genevieve Forster, Department of Clinical Sciences
Name: Erica Borreson, Colorado School of Public Health